SEQUENTIAL SARS-COV-2 MRNA VACCINATION INDUCES ANTI-IDIOTYPE (ANTI-ACE2) ANTIBODIES IN K18 HUMAN ACE2 TRANSGENIC MICE

Sequential SARS-CoV-2 mRNA Vaccination Induces Anti-Idiotype (Anti-ACE2) Antibodies in K18 Human ACE2 Transgenic Mice

Background/Objectives: Novel mRNA vaccines have been successfully utilized to curtail the SARS-CoV-2 pandemic.However, the immunology underlying CoV2 vaccinations, particularly with repeated boosting, has not been properly characterized due to limitations in the preclinical modeling of SARS-CoV-2 infection/vaccinations as well as constantly changin

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